Prothrombin Time in Dicoumarol Therapy
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چکیده
منابع مشابه
Prothrombin Time in Dicoumarol Therapy.
In the course of controlling dicoumarol therapy given (a) as a postoperative routine to prevent thrombosis (fifty-five cases) and (b) therapeutically in cases of established venous thrombosis (nine cases), certain peculiarities have been observed in the behaviour of the prothrombin time, particularly in relation to dicoumarol haemorrhage. Two sources of thromboplastin have been used, Russell vi...
متن کاملVitamin K and the biosynthesis of prothrombin. II. Structural comparison of normal and dicoumarol-induced bovine prothrombin.
Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...
متن کاملComparison of the native prothrombin antigen and the prothrombin time for monitoring oral anticoagulant therapy.
We have measured the fully carboxylated (native) prothrombin antigen and the undercarboxylated (abnormal) prothrombin antigen in patients treated with sodium warfarin using specific immunoassays to evaluate a new approach for monitoring oral anticoagulant therapy. Plasma and serum samples (391) were assayed for the prothrombin time, native prothrombin antigen, and abnormal prothrombin antigen. ...
متن کاملVitamin K and the biosynthesis of prothrombin. IV. Isolation of peptides containing prosthetic groups from normal prothrombin and the corresponding peptides from dicoumarol-induced prothrombin.
The 25,000 Af, fragment obtained by thrombin digestion of normal prothrombin has been further compared with the corresponding fragment from dicoumarol-induced prothrombin. In contrast with the fragment from normal prothrombin, the one from dicoumarol-induced prothrombin does not bind calcium (STENFLO, J. (1973) /. Biol. Chem. 248, 6325). After cyanogen bromide degradation of this material, a fr...
متن کاملProthrombin Time in Normal Indians
Dam and his colleagues (1934, 1936) were the first to show the important role of vitamin K in the synthesis of prothrombin in the liver. Numerous studies by Hawkins and Brinkhous (1936), Dam and Glavind (1938), Zuckerman et al. (1939), and Clark et al. (1939) have since established the efficiency of this vitamin in combating certain hsemorrhagic states, characterized by lowered prothrombin leve...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1949
ISSN: 0021-9746
DOI: 10.1136/jcp.2.1.45